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描述
研究领域
,Recombinant-Protein
图片与验证
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关键属性
−| 表达系统 | E. coli |
|---|---|
| 生物学来源 | Human |
| 生物学活性 | The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain. |
| 标签 | Tag Free |
| 表达区域 | Ala19-Arg247(R125A,R127A,R128A) |
| MW | 28 KDa (reducing condition) |
| 纯度 | 99.00% |
| 蛋白序列 | Ala19-Arg247(R125A,R127A,R128A) |
储存与操作
−| 储存 | -20°C |
|---|---|
| 有效期 | 6 months from date of receipt. |
| 免责声明 | For research use only |
相似产品
−- Item 1 of 3
Human pro-BDNF Protein [orb1471731]
Greater than 95% as determined by reducing SDS-PAGE.
25.6 KDa
Mammalian
10 μg, 50 μg Human BDNF protein [orb391293]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
E. coli
500 μg, 50 μg, 10 μg
质量保证
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常用数据库链接
UniProt
UniProt 详情
−暂无 UniProt 数据
