TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A/TNFSF15/VEGI has been reported as a marker of poor prognosis in breast cancer.
图片与验证
−
Item 1 of 3
已测应用
IHC-P
稀释范围
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
反应性
Human
应用说明
Titration of the recombinant TL1A antibody may be required for optimal performance.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
关键属性
−
抗体类型
Primary Antibody
宿主
Mouse
克隆性
Recombinant
同种型
Mouse IgG1, kappa
克隆号
rVEGI/1283
免疫原
A full length human recombinant protein was used as the immunogen for this recombinant TL1A antibody.
纯度
Protein G affinity chromatography
偶联
Unconjugated
储存与操作
−
储存
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
缓冲液/防腐剂
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
有效期
12 months from date of receipt.
危害信息
This recombinant TL1A antibody is available for research use only.
Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.