BTRC Antibody (N-term)

SKU: orb134924

描述

Rabbit polyclonal to BRTC1/2. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at Lys-21 and Lys-22. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

研究领域

Product Categories/Products/Antibodies,Product Categories/Research Area,Neuroscience,Signaling Pathways,Product Categories/Products/Antibodies/Primary Antibodies,Signaling Pathways/Wnt,Infectious Diseases,Crown Antibodies;Primary Antibodies;Antibody Collections;Cell Biology;Microbiology;Neuroscience;Anti-Wnt-Pathway (plus Lgr5) Antibodies;Viral process;Host-virus interaction

图片与验证

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Item 1 of 1

已测应用	WB
稀释范围	WB: 1:1000
反应性	Human
预测反应性	Mouse

关键属性

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宿主	Rabbit
克隆性	Polyclonal
同种型	Rabbit IgG
免疫原	Synthetic Peptide
靶点	BTRC
分子量	68867
偶联	Unconjugated

储存与操作

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储存	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
形态/外观	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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anti BTRC antibody, anti BTRCP antibody, anti FBW1A antibody, anti FBXW1A antibody, anti F-box/WD repeat-containing protein 1A antibody, anti F-box/WD repeat-containing protein 1A antibody, anti E3RSIkappaB antibody, anti F-box/WD repeat-containing protein 1A antibody, anti Epididymis tissue protein Li 2a antibody, anti F-box/WD repeat-containing protein 1A antibody, anti F-box and WD repeats protein beta-TrCP antibody, anti F-box/WD repeat-containing protein 1A antibody, anti pIkappaBalpha-E3 receptor subunit antibody

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质量保证

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常用数据库链接

基因符号

BTRC

UniProt

Q9Y297

RefSeq（蛋白）：NP_003930.1, NP_378663.1

UniProt 详情

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暂无 UniProt 数据

NCBI 参考序列

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实验方案信息

免疫印迹（WB）

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应用：	IF, IHC-P, WB
预测反应性：	Mouse
反应性：	Human
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated

应用：	WB
预测反应性：	Mouse, Other, Rat, Zebrafish
反应性：	Human
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated

应用：	WB
反应性：	Human, Mouse
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated