CTNNB1 Antibody (N-term)

SKU: orb106921

描述

Rabbit polyclonal to CTNNB1. Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.

研究领域

Product Categories/Products/Antibodies,Product Categories/Research Area,Neuroscience,Signaling Pathways,Product Categories/Products/Antibodies/Primary Antibodies,Signaling Pathways/Wnt,Epigenetics,Infectious Diseases,Primary Antibodies;Cancer;Cardiovascular;Neuroscience;Signal Transduction;Anti-Wnt-Pathway (plus Lgr5) Antibodies

图片与验证

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已测应用	WB
稀释范围	WB: 1:1000
反应性	Human
预测反应性	Mouse, Other, Rat, Zebrafish

关键属性

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抗体类型	Primary Antibody
宿主	Rabbit
克隆性	Polyclonal
同种型	Rabbit IgG
克隆号	RB41157
免疫原	Synthetic Peptide
靶点	CTNNB1
分子量	85497
偶联	Unconjugated

储存与操作

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储存	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
形态/外观	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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anti CTNNB1 antibody, anti CTNNB antibody, anti Catenin beta-1 antibody, anti Catenin beta-1 antibody, anti Beta-catenin antibody

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Mouse, Other, Rat, Zebrafish
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应用：
WB
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Mouse, Other, Rat, Zebrafish
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质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

常用数据库链接

基因符号

CTNNB1

UniProt

P35222

RefSeq（蛋白）：NP_001091680.1, NP_001895.1, NP_001091679.1

UniProt 详情

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暂无 UniProt 数据

NCBI 参考序列

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实验方案信息

免疫印迹（WB）

查看实验方案

查看更多实验方案

应用：	FC, IF, IHC-P, WB
预测反应性：	Mouse, Other, Rat, Zebrafish
反应性：	Human
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated

应用：	WB
预测反应性：	Mouse
反应性：	Human
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated